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pentobarbital will reduce the extent or outcome of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Potent or average CYP3A4 inducers might improve rate of diazepam elimination; hence, efficacy of diazepam could be decreased.pentobarbital will reduce the extent or influence of diltiazem by affecti